New publication on morphological profiling revealing neuroprotection via mitochondrial uncoupling in human dopaminergic neurons

In collaboration with the University of Luxembourg, Ksilink used a patient-derived cellular model for Parkinson’s Disease based on SNCA triplication and isogenic control mDA neurons to identify and rescue multiple phenotypes. Our pilot screen of > 1000 compounds revealed several compounds restoring healthy phenotypes, increasing Tyrosine hydroxylase (TH) and decreasing α-synuclein (αSyn) levels. Several hits were linked to mitochondrial biology. 

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