Ksil20@Nw-wsite, auteur sur Ksilink https://www.ksilink.com/author/ksil20nw-wsite/ Patient-based drug discovery Tue, 07 Jan 2025 14:17:00 +0000 en-US hourly 1 https://www.ksilink.com/wp-content/uploads/2020/09/cropped-favicon-ksilink-32x32.png Ksil20@Nw-wsite, auteur sur Ksilink https://www.ksilink.com/author/ksil20nw-wsite/ 32 32 Join Ksilink at BIO Partnering @ JPM Week 2025! https://www.ksilink.com/bio-partnering-jpm-week-2025/ https://www.ksilink.com/bio-partnering-jpm-week-2025/#respond Thu, 02 Jan 2025 10:13:52 +0000 https://www.ksilink.com/?p=6374 We are excited to announce that Mona Boyé, Head of BD & Partnerships, and Johannes Wilbertz, Team Leader Neuroscience, will be attending BIO Partnering @ JPM Week in San Francisco from January 13-16, 2025. This event is a leading gathering for the biotechnology industry, offering unparalleled opportunities for networking, partnering, and advancing business development goals. […]

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We are excited to announce that Mona Boyé, Head of BD & Partnerships, and Johannes Wilbertz, Team Leader Neuroscience, will be attending BIO Partnering @ JPM Week in San Francisco from January 13-16, 2025. This event is a leading gathering for the biotechnology industry, offering unparalleled opportunities for networking, partnering, and advancing business development goals.

About Ksilink: Ksilink is at the forefront of patient-based drug discovery, designing and applying unique cellular assays for large-scale phenotypic screening. Our proprietary drug discovery engine, powered by AI-driven image analysis, aims to generate the most efficient first-in-class therapeutic molecules for next-generation medicine leveraging our extensive network of academic and clinical partners across Europe.

We look forward to connecting with you in San Francisco to explore new opportunities and collaborations!

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Ksilink Advances PMDS Research and Disease Modelling https://www.ksilink.com/ksilink-advances-pmds-research-and-disease-modelling/ https://www.ksilink.com/ksilink-advances-pmds-research-and-disease-modelling/#respond Tue, 11 Jun 2024 08:05:25 +0000 https://www.ksilink.com/?p=5838 Strasbourg, France – Ksilink, together with our collaborators from I-Stem (Paris), has recently published a scientific paper that provides significant insights into Phelan-McDermid syndrome (PMDS), a genetic disorder that presents complex challenges in neurodevelopment and synaptic function. The research focuses on the SHANK3 gene, which is crucial for the proper development of neural connections. SHANK3 […]

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Strasbourg, France – Ksilink, together with our collaborators from I-Stem (Paris), has recently published a scientific paper that provides significant insights into Phelan-McDermid syndrome (PMDS), a genetic disorder that presents complex challenges in neurodevelopment and synaptic function.

The research focuses on the SHANK3 gene, which is crucial for the proper development of neural connections. SHANK3 deficiency is a common factor in PMDS, leading to a range of developmental abnormalities. Our study detailed the developmental and synaptic disruptions caused by SHANK3 mutations and used a chemical genomics approach to identify potentially causative cellular pathways.

A key aspect of the research is the identification of small molecular compounds that can address the hyperdifferentiation phenotype seen in SHANK3 deficiency. Among these, one molecule has been highlighted for its ability to positively influence synapse formation and correct neurodevelopmental pathways potentially via influencing cellular actine dynamics.

Ksilink researchers will continue to explore the cellular biology of SHANK3-deficient cells. The identified compounds together with the used cell lines provide a model for understanding the effects of SHANK3 deficiency and hold potential for future development into therapeutic interventions.

Ksilink remains dedicated to advancing the understanding of PMDS and contributing to the broader field of drug discovery. Through continued research and collaboration, we aim to provide valuable models and tools that can aid in the development of effective treatments for PMDS and related disorders.

Our scientific paper can be accessed here: https://rdcu.be/dKnYt

For further details on our research, please visit our website or reach out to us.

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Artificial Intelligence in Mental Health Summit, July 1st and 2nd, Berlin https://www.ksilink.com/ai-summit-mental-health-berlin-2024/ https://www.ksilink.com/ai-summit-mental-health-berlin-2024/#respond Thu, 23 May 2024 14:22:31 +0000 https://www.ksilink.com/?p=5809 Join us for a two-day free event examining the role played by artificial intelligence and digital tools in understanding and supporting mental health. Hosted by the environMENTAL EU Project, Deutsches Zentrum für Psychische Gesundheit (DZPG) and EBRAINS, this event brings together experts within the field of mental health research, practice and policy. More information can […]

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Join us for a two-day free event examining the role played by artificial intelligence and digital tools in understanding and supporting mental health. Hosted by the environMENTAL EU Project, Deutsches Zentrum für Psychische Gesundheit (DZPG) and EBRAINS, this event brings together experts within the field of mental health research, practice and policy.

More information can be found ‘here

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02.04.2024: World Autism Awareness Day https://www.ksilink.com/world-autism-day/ https://www.ksilink.com/world-autism-day/#respond Tue, 02 Apr 2024 13:39:57 +0000 https://www.ksilink.com/?p=5741 Link to photo source (UN) At Ksilink, it is one of our core missions to develop new therapeutic modalities to treat autism and particularly a rare form called Phelan McDermid Syndrome (PMDS). In line with the principle of the 3R, we developed a relevant human stem cell-derived neuronal model that recapitulates disease features with our […]

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Link to photo source (UN)

At Ksilink, it is one of our core missions to develop new therapeutic modalities to treat autism and particularly a rare form called Phelan McDermid Syndrome (PMDS). In line with the principle of the 3R, we developed a relevant human stem cell-derived neuronal model that recapitulates disease features with our collaborators at I-Stem (Establishment of heterozygous and homozygous SHANK3 knockout clonal pluripotent stem cells from the parental hESC line SA001 using CRISPR/Cas9 – ScienceDirect; Pharmacological modulation of developmental and synaptic phenotypes in human SHANK3 deficient stem cell-derived neuronal models | bioRxiv).

The deficit in SHANK3 protein (haploinsufficiency) which is a master scaffolding protein found in the postsynaptic density of excitatory synapses, is recognized as one of the major causes for different forms of autism including PMDS. Our current goal is to normalize the SHANK3 protein levels to physiological levels.
If you want to know more about us and our journey to treat PMDS, please contact us: contact@ksilink.com.

 

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New Study on the Impact of Endocrine Disrupting Chemicals on Parkinson’s Disease https://www.ksilink.com/new-study-on-the-impact-of-endocrine-disrupting-chemicals-on-parkinsons-disease/ https://www.ksilink.com/new-study-on-the-impact-of-endocrine-disrupting-chemicals-on-parkinsons-disease/#respond Mon, 11 Dec 2023 15:26:14 +0000 https://www.ksilink.com/?p=5518 New Study on the Impact of Endocrine Disrupting Chemicals on Parkinson’s Disease Ksilink, in collaboration with researchers from the University of Chieti in Italy, has published a new study on the effects of Endocrine Disrupting Chemicals (EDCs) on human stem cell-derived neurons. The research focused on bisphenols (BPs) and perfluoroalkyls (PFs), chemicals found in plastics […]

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New Study on the Impact of Endocrine Disrupting Chemicals on Parkinson’s Disease

Ksilink, in collaboration with researchers from the University of Chieti in Italy, has published a new study on the effects of Endocrine Disrupting Chemicals (EDCs) on human stem cell-derived neurons.

The research focused on bisphenols (BPs) and perfluoroalkyls (PFs), chemicals found in plastics and household products. The team analyzed their effects on human stem cell-derived midbrain dopaminergic neurons (mDANs), a cell type affected in Parkinson’s Disease (PD).

Using machine learning (ML), the team classified EDC-treated versus control mDANs based on 126 different phenotypic features. The results showed that EDC-treated mDANs were identified with high accuracies (0.88–0.96), indicating that EDCs induce changes in these cells.

The study found that EDC exposure led to an increase in alpha-synuclein (αSyn) and tyrosine hydroxylase (TH) staining intensity within the neurons, and a decrease in microtubule-associated protein 2 (MAP2) neurite length and branching. These changes are characteristic of PD, suggesting that EDCs may play a role in the disease’s development.

This study shows that using human stem cells to create models of neurons, along with high-content imaging, can help to spot changes in these cells when they are exposed to different chemicals. This method could be very useful in the process of discovering and prioritizing new drug-like molecules or detecting unwanted effects early on.

Link to study: https://www.nature.com/articles/s41598-023-49364-y

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Review Article in JAMA Psychiatry https://www.ksilink.com/review-article-in-jama-psychiatry/ https://www.ksilink.com/review-article-in-jama-psychiatry/#respond Thu, 12 Oct 2023 12:49:37 +0000 https://www.ksilink.com/?p=5266 Schumann G, Andreassen OA, Banaschewski T, et al. Addressing Global Environmental Challenges to Mental Health Using Population Neuroscience: A Review. JAMA Psychiatry. 2023;80(10):1066–1074. The new review paper from the environMENTAL EU Project in JAMA Psychiatry emphasizes how interdisciplinary research can help to unravel underlying mechanisms of environmentally-related mental illness. Climate change, pollution, urbanization, socioeconomic inequality, […]

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Schumann G, Andreassen OA, Banaschewski T, et al. Addressing Global Environmental Challenges to Mental Health Using Population Neuroscience: A Review. JAMA Psychiatry. 2023;80(10):1066–1074.

The new review paper from the environMENTAL EU Project in JAMA Psychiatry emphasizes how interdisciplinary research can help to unravel underlying mechanisms of environmentally-related mental illness. Climate change, pollution, urbanization, socioeconomic inequality, and psychosocial effects of the COVID-19 pandemic have caused massive changes in environmental conditions that affect brain health during the life span, both on a population level as well as on the level of the individual. How these environmental factors influence the brain, behavior, and mental illness is not well known. The research strategies reviewed here will lead to the development of objective biomarkers and evidence-based interventions that will significantly improve outcomes of environment-related mental illness.

Link to article

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Press Release of the IMPACT consortium, engaged in finding novel therapies to fight Arrhythmogenic Cardiomyopathy https://www.ksilink.com/press-release-of-the-impact-consortium-engaged-in-finding-novel-therapies-to-fight-arrhythmogenic-cardiomyopathy/ https://www.ksilink.com/press-release-of-the-impact-consortium-engaged-in-finding-novel-therapies-to-fight-arrhythmogenic-cardiomyopathy/#respond Thu, 12 Oct 2023 12:23:04 +0000 https://www.ksilink.com/?p=5259 Thanks to the funding obtained from Horizon Europe, this research project aims to open up new therapeutic perspectives based on the results obtained from various disease models. We are happy to take part in this innovative and multidisciplinary project, whose success is strongly supported by the diverse but complementary expertise of partners from academic institutions […]

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Thanks to the funding obtained from Horizon Europe, this research project aims to open up new therapeutic perspectives based on the results obtained from various disease models.
We are happy to take part in this innovative and multidisciplinary project, whose success is strongly supported by the diverse but complementary expertise of partners from academic institutions and leading companies in the fields of computer.

For more information, please read our press release.

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]]> https://www.ksilink.com/press-release-of-the-impact-consortium-engaged-in-finding-novel-therapies-to-fight-arrhythmogenic-cardiomyopathy/feed/ 0 New publication in “Nature Communications” https://www.ksilink.com/new-publication-in-nature-communications/ https://www.ksilink.com/new-publication-in-nature-communications/#respond Thu, 12 Oct 2023 09:25:37 +0000 https://www.ksilink.com/?p=5253 Lamiable, A., Champetier, T., Leonardi, F. et al. Revealing invisible cell phenotypes with conditional generative modeling. Nat Commun 14, 6386 (2023). Biological sciences, drug discovery and medicine rely heavily on cell phenotype perturbation and microscope observation. However, most cellular phenotypic changes are subtle and thus hidden from us by natural cell variability: two cells in […]

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Lamiable, A., Champetier, T., Leonardi, F. et al. Revealing invisible cell phenotypes with conditional generative modeling. Nat Commun 14, 6386 (2023).

Biological sciences, drug discovery and medicine rely heavily on cell phenotype perturbation and microscope observation. However, most cellular phenotypic changes are subtle and thus hidden from us by natural cell variability: two cells in the same condition already look different. In this study, we show that conditional generative models can be used to transform an image of cells from any one condition to another, thus canceling cell variability. We visually and quantitatively validate that the principle of synthetic cell perturbation works on discernible cases. We then illustrate its effectiveness in displaying otherwise invisible cell phenotypes triggered by blood cells under parasite infection, or by the presence of a disease-causing pathological mutation in differentiated neurons derived from iPSCs, or by low concentration drug treatments. The proposed approach, easy to use and robust, opens the door to more accessible discovery of biological and disease biomarkers.

Link to article

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Meet us at ECNP Barcelona! https://www.ksilink.com/ecnp-barcelona-7-10-october-2023/ https://www.ksilink.com/ecnp-barcelona-7-10-october-2023/#respond Mon, 02 Oct 2023 07:09:46 +0000 https://www.ksilink.com/?p=5248 Ksilink will be part of the 36th ECNP Congress in Barcelona, from October 7th to 10th 2023. Meet Karen Schmitt at the poster P.0070 during the poster session on 08/10/23, 12:35 – 14:00 to know about Ksilink and how we can empower you research with High-throughput/ High-content phenotypic profiling of stem-cell-derived neuronal cultures. Browse the […]

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Ksilink will be part of the 36th ECNP Congress in Barcelona, from October 7th to 10th 2023.
Meet Karen Schmitt at the poster P.0070 during the poster session on 08/10/23, 12:35 – 14:00 to know about Ksilink and how we can empower you research with High-throughput/ High-content phenotypic profiling of stem-cell-derived neuronal cultures.
Browse the complete programme: www.ecnp.eu/programme2023
See you in Barcelona or virtually!

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New publication in the journal ‘Stem Cell Research’ https://www.ksilink.com/new-publication-in-the-journal-stem-cell-research/ https://www.ksilink.com/new-publication-in-the-journal-stem-cell-research/#respond Mon, 02 Oct 2023 07:07:05 +0000 https://www.ksilink.com/?p=5245 Chatrousse et al., Establishment of heterozygous and homozygous SHANK3 knockout clonal pluripotent stem cells from the parental hESC line SA001 using CRISPR/Cas9. https://doi.org/10.1016/j.scr.2023.103209 Phelan-McDermid syndrome (PMS) is a rare genetic disease characterized by a global developmental delay with autism spectrum disorder. PMS is caused by loss of function mutations in the SHANK3 gene leading to […]

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Chatrousse et al., Establishment of heterozygous and homozygous SHANK3 knockout clonal pluripotent stem cells from the parental hESC line SA001 using CRISPR/Cas9. https://doi.org/10.1016/j.scr.2023.103209

Phelan-McDermid syndrome (PMS) is a rare genetic disease characterized by a global developmental delay with autism spectrum disorder. PMS is caused by loss of function mutations in the SHANK3 gene leading to SHANK3 protein haploinsufficiency. This study describes the generation of isogenic clones produced from one male human embryonic stem cell line with deletions in SHANK3, in a heterozygous or homozygous manner, using CRISPR/Cas9 indel methodology. Differentiation of these clones into different neuronal lineages will help understanding PMS etiology and find treatments for PMS patients.

Article link: https://authors.elsevier.com/sd/article/S1873-5061(23)00195-2

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